BRD9: A new gene target & biomarker for prostate cancer?

Prostate cancer. Phase II. ARV-471. ... And the translocation’s ability to cause cancer appears to be dependent on BRD9. ... “Helios is an attractive cancer target, both because of its role in ... Summary and conclusions: BRD9 has potential as a diagnostic and prognostic biomarker in prostate cancer. BRD9 also shows promise as a therapeutic target, particularly in advanced prostate cancer, and as a co-target alongside other genes in the SWI/SNF and BET complexes, and those in common prostate cancer signalling pathways. Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of many cancers. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immune checkpoint that plays an important role in tumor immune escape by modulating multiple immune cells and is considered an attractive target for cancer immunotherapy. Add New Company. Cancel Add Company. Version 1.0.0 Synapse is a platform for supporting scientific collaborations centered around shared biomedical data sets. Our goal is to make biomedical research more transparent, more reproducible, and more accessible to a broader audience of scientists. Synapse serves as the host site for a variety of scientific collaborations, individual research projects, and DREAM challenges. BRD4 is a promising therapeutic target in multiple cancer types, e.g., CRPC 202 and pancreatic cancer 203. Compound 54 completely degraded BRD4 at 10 nmol/L within 6 h (DC 50 <1 nmol/L). In a word, 54 can efficiently lead to degradation of pathogenic proteins. In 2020, Arvinas presented interim results of a Phase 1/2 clinical trial of their front-line PROTAC, ARV-110, in men with metastatic castration-resistant prostate cancer (mCRPC) and showed two patients achieving responses in prostate-specific antigen (PSA) levels. 6,7 This landmark result showed pharmacological efficacy of PROTACs in the clinic ... High-content imaging of malaria-infected red blood cells (RBCs) using the Amnis ImageStream X MKII system is presented. Background, upper half: montage of PBS-treated control cells revealing purple nuclear (Hoechst) and green punctate digestive vacuole calcium (Fluo-4) features. Lower half: montage of chloroquine-treated cells revealing purple nuclear (Hoechst) and redistributed calcium (Fluo ... Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the degradation of select proteins of interest (POIs) by hijacking the activity of E3 ubiquitin ligases for POI ubiquitination and subsequent degradation by the 26S proteasome. New Tag Name . Cancel Create ... Treatment Target. ... Pulmonary Multiple myeloma Acute Lymphoblastic Leukemia Chronic Lymphoblastic Leukemia Metabolic Diseases Colorectal Cancer Prostate Cancer Urology Women's Health Antimicrobial Resistance NSCLC HPV-positive cancers Solid Tumors Mast cell Diseases Multiple Melanoma B-Cell Lymphomas GBM HIV ...

2021.12.02 10:21 Susan_Heavey BRD9: A new gene target & biomarker for prostate cancer?

BRD9: A new gene target & biomarker for prostate cancer? submitted by Susan_Heavey to CancerBiology [link] [comments]

2021.12.02 10:21 marg9 It just dawned on me - alcohol is an NMDA-receptor antagonist, a binge is akin to getting a Ketamine infusion which is also an NMDA receptor antagonist, and it's used as antidepressant. (Originally from r/hangovereffect, meaning people who get antidepressant effect day after drinking alcohol.)

submitted by marg9 to depressionregimens [link] [comments]

2021.12.02 10:21 Mynewsify-Website Virat Kohli returns as New Zealand eye elusive series win in India, Cricket news from ESPN

Virat Kohli returns as New Zealand eye elusive series win in India, Cricket news from ESPN submitted by Mynewsify-Website to MynewsifyNews [link] [comments]

2021.12.02 10:21 blogs_bunny Greens senator Lidia Thorpe apologises for ‘disgusting’ comment directed at Liberal Hollie Hughes #Labor #Senate #Channel #Senator #ScottMorrison #Two #Amanda #Thursday #Greens #Van #today #thenewyear #thisweek

Greens senator Lidia Thorpe apologises for ‘disgusting’ comment directed at Liberal Hollie Hughes #Labor #Senate #Channel #Senator #ScottMorrison #Two #Amanda #Thursday #Greens #Van #today #thenewyear #thisweek submitted by blogs_bunny to blogsbunny [link] [comments]

2021.12.02 10:21 vonBenold EBay Kleinanzeigen - Mac Mini Verkauf

Moin zusammen,
ich hab vor zwei Tagen einen Mac Mini von 2014 verkauft. Der Käufer hat den Mac abgeholt und bar bezahlt. Jetzt sagt er, dass der Mac nicht angehen würde. Ich weiß zu 100%, dass der Mac lief. Ich hab auch noch das Foto mir Seriennummer, das 3 Tage als ist.
Er hat die Ware gekauft wie gesehen oder?
submitted by vonBenold to LegaladviceGerman [link] [comments]

2021.12.02 10:21 ShortAlgoBear Nice chart! Monitoring for a buy entry on $INVA with UltraAlgo.

Nice chart! Monitoring for a buy entry on $INVA with UltraAlgo. submitted by ShortAlgoBear to UltraAlgo [link] [comments]

2021.12.02 10:21 AstronautCurrent408 People are idiots. IT IS TO BE PUBLISHED IN A JOURNAL THEY CANT GIVE IT OUT FIRST. Why do you care if the release comes now or tomorrow as long as they do it and it is good? Jfc

People are idiots. IT IS TO BE PUBLISHED IN A JOURNAL THEY CANT GIVE IT OUT FIRST. Why do you care if the release comes now or tomorrow as long as they do it and it is good? Jfc submitted by AstronautCurrent408 to VXRT [link] [comments]

2021.12.02 10:21 brihow84 Anyone hungry? 😋😂

Anyone hungry? 😋😂 submitted by brihow84 to theyknew [link] [comments]

2021.12.02 10:21 Electrical_Guess9648 🐯 BABY TIGER COIN 🐯 100% Doxxed | Hilarious NFT Character Cards | Huge Marketing Team | Full Audit | Huge Telegram Growth | Amazing New

🐯 BABY TIGER COIN ($BTC/BNB) just launched and our community is organically growing super fast! Grab yourself a Natty Ice, unzip those jorts, and slick back that sweaty mullet because you’re in for one hell of a ride (mustaches sold separately).

Featuring a hilarious NFT collection and unique rewards for holding, the U.S. based Florida Man project is delivered by a team of 100% doxxed developers, and their full-time graphic artist is constantly adding new characters.

It's a great coin to you!

🐯 Submitted to TEN NEW LISTING SITES!! Super Stoked and Trashy Telegram Group. Healthy Chart with Ample LP and Solid Floors. 4 More Call Groups today. (2) TikTok influencers Paid. (4) Twitter Influencers Paid. (2) Full-time artists working round-the-clock. CoinGecko and CoinMarketCap Incoming. First Video AMA went great, another one coming Friday!

Some $BTC NFT Highlights:

🐯 Boxed sets of character cards, each of these dirtbags having different rarities, traits, and backstories.

Collecting an entire set unlocks crazy rewards, and certain Characters “link” together to release instant BNB prizes to the holder’s wallet.

Aside from the sets, we will also MintDrop super rare cards, which you can buy/sell/trade on marketplaces that we partner with.

🐯 NFT holders will be entered into our permanent weekly giveaway contests, where they will be broadcast on our livestream channel. Prizes range from BNB , $BTC , and real-life tangible goods.

NFT farming will commence in phase II, and will start developing our online game which willreward holders in $BTC in phase II.I

🎯 Tokenomics:

Total Supply: 1,000,000,000

🔥 Burn : 20%

🔒Liquidity Locked 100%

✅ Tax : 7%

Come join our community on TG..

🌎 Telegram:

🔰 Pancake Swap :


🔰 Deeplock: Lock LP

Game Swap, Game Farm, Game Merch and many more coming in the project roadmap🚀

Good Luck!! 🌟
submitted by Electrical_Guess9648 to CryptocurrencyICO [link] [comments]

2021.12.02 10:21 Longjumping-Pin-9974 would like to ask

Hey guys, i would like to ask if u know any exchanges or sites where i can join some tournaments with other mates and compete in trade? One user advised 2 do it on lottrade but I have never been on this site before idk. Mb sb knows more about lot trade? Thanks
submitted by Longjumping-Pin-9974 to BitcoinBeginners [link] [comments]

2021.12.02 10:21 I-am-Any0ne Diamine Inkvent - Day 2 - Garland, some similar inks added for comparison

submitted by I-am-Any0ne to fountainpens [link] [comments]

2021.12.02 10:21 UltraPokemaster After having relapsed 3 times I now know why I do NoFap! I do NoFap to be a better person. DONE.

So I was on a 14 day streak and I was watching some videoes on debunking NoFap. To be honest they made some good points about the scientific research the "Fapstronauts". So does Nofap help? maybe No, for people it just wont help. But for some like me it has helped me a lot. I had a lot of OCD and deppression sadly. A bit tragic was that I relapsed because I thought I was not so bad to relapse as I maybe feared, because of the videoes I watched.

But now after having relapsed for the third time I now know why I do NoFap, and no it has nothing to do with dopamine, motivation, being more attractive or anything like that. It is quite simple I just want to be a better person. A person who does not need any PMO to be happy. So in conclusion I dont know if science supports NoFap or not, but at the end of the day that does not matter to me, because it is about being your true self.
submitted by UltraPokemaster to NoFap [link] [comments]

2021.12.02 10:21 Blackburn843 IWFTR (NEED THE NAME)

IWFTR (NEED THE NAME) submitted by Blackburn843 to whatshername [link] [comments]

2021.12.02 10:21 Mynewsify-Website Rory McIlroy defends players’ right to play in Saudi Arabia tournament, – RSS Channel – Sport

Rory McIlroy defends players’ right to play in Saudi Arabia tournament, – RSS Channel – Sport submitted by Mynewsify-Website to MynewsifyNews [link] [comments]

2021.12.02 10:21 theallrounder360 Infinite loading dots then black screen when using link on quest 2

So I just upgraded to quest 2 from PSVR and adoring it so far, however, one of the first things I did was try to hook it up with link as I've got a lot of PCVR compatible games, however when I connected the cable, I was promoted to start link, it showed up on my PC and quest, and then just 3 loading dots for around a minute, I assumed this is what happened when you weren't in a game, however upon trying to open a game, just a black screen appeared. This happened with everything I tried, different USBs and air link. My PC is definitely compatible as I've got a 3060 mobile and a 5900hs (not to mention my laptop is advertised as VR ready and both oculus and steam told me I was good). I'd really like to get this working and any help would be much appreciated.
submitted by theallrounder360 to OculusQuest [link] [comments]

2021.12.02 10:21 Impossible-Bad-8551 💎 Mini Raca Just Launched 5 Minutes 🚀 Ultra Low Cap with chary only goes up 💎 Ready For Going To Moon 💎 Don't miss this | 1500X Gemmmmm!

Are you tired of fake projects, rug pull and shit/meme tokens?
A losing investor saying `` We also missed this train '' Don't miss it now ❗️
⭐️ Five reasons for smart investors ⭐️
1️. Mutual agreement news with hotels, casinos and tourism agencies including usage areas
2️. Strong team of engineers and marketers
3️. Original and comprehensive whitepaper
4️. Mobile app
What's MRACA Protocol ?
MRACA protocol aims to create a system where users can benefit from discounts and special privileges thanks to the mobile application that will be created with tourism agencies, hotels, airline companies and casinos.
For use in hotel reservations, flight tickets and casino expenses all over the world. MRACA Protocol , which has already distinguished its place among the most powerful coins in Binance Smart Chain , carries out strategies to maximize the satisfaction of its investors and users with the smart contract it creates.
🟡 Token Information 🟡
Name / Symbol : Mini RACA / MINIRACA
Total Supply : 1,000,000,000
Type : BEP20
📱 Mobile App
✅ Coingecko / CoinMarketCap
🎯 Coinsniper
🎯 Coinhunter
💎 Contract: 0x4feFB35c467a41b5E94a7783C09F396579BCD5D0
💎 Pancakeswap :
💎 Renounced Ownership:
submitted by Impossible-Bad-8551 to AllCryptoBets [link] [comments]

2021.12.02 10:21 freedom_fruit Good morning/afternoon/evening wherever you are 🌍

Good morning/afternoon/evening wherever you are 🌍 submitted by freedom_fruit to Faces [link] [comments]

2021.12.02 10:21 slimshady32345 Macintosh Plus 2k20 by yung frown is my most listened song for the second time now lmao

submitted by slimshady32345 to teenagersbutpog [link] [comments]

2021.12.02 10:21 Sure-Working5163 IOS 15 sms Sender issue!

I use to run a shorthcut function on my sms “Every time I receive an sms from my bank with a certain keyword > it copies it and paste it to my note”. Since I have updated to IOS 15 the shortcut no longer works! Bank sms sender has identity so I assume that is why it is not working. Anyone else facing the same issue?
submitted by Sure-Working5163 to shortcuts [link] [comments]

2021.12.02 10:21 nicholast88 LPT: Microwave food on half power for double the time

If you find that heating food in the microwave either produces a dish with fridge cold bits and other parts hotter than the sun, try setting your microwave to 50% power and doubling the time you heat it for.
This way the food will be much more evenly heated.
This also applies if you find microwaving food makes it too dry.
submitted by nicholast88 to LifeProTips [link] [comments]

2021.12.02 10:21 Mrmcgriddle223 we rocking with it?

we rocking with it? submitted by Mrmcgriddle223 to YoungThug [link] [comments]

2021.12.02 10:21 SPTudoMaisAdvogado Vale para o Twitter tb

Vale para o Twitter tb submitted by SPTudoMaisAdvogado to brasilivre [link] [comments]

2021.12.02 10:21 drynionph ✊$RoninGamez – Just got listed in CMC! ⭐ | ⚡ Launching Now on BSC | All NFTs will be out made by lead dev ❤Alex Lopez – in charge of Magic the Gathering, NBA 2k, NFL 2k☀︎ | Revolutionary gaming and NFT eco-system | ☄︎ Liquidity Lock | ☑︎Next x100

Join the bullrun! $RoninGamez is currently on upstreak as they got listed on CMC
Get into the community to experience the upcoming utility presentation
Waste no time and take hold of the precious $RONINGMZ tokens while they are still hot!
☘︎Where to buy? Pancakeswap with 8% slippage! ☠︎
✖ What is Ronin Games?
Ronin Games is a multi-player gaming and NFT ecosystem created to revolutionize the field of Parimutuel betting.
Ronin Gamez is building a platform to bring together the best aspects of Crypto, Gaming, NFTs & Betting. The RONIN token will serve as the native utility token on the platform, being used for, but not limited to, interacting with the games by purchasing upgrades & NFTs, betting, voting/governance, staking and more.
♾ Who is their main dev? He is a world know figure in the gaming world!
His main lead gaming developer is – Alex Lopez. He was responsible for major computer video games like “Magic the gathering”, “NBA 2k”, “NFL 2k”.

❤️Tokenomics - Roninomics:
☝️Total Supply: 100,000,000
☝️Tax -6%: 2% Auto liquidity, 4% Marketing
☝️Secure – Time base tokenism solve anti-pump and dump, paper hands, sniper bots
☝️Robust – Airdrop rewards for diamond holders
♻⛩️Total Distribution:
♨️ Private Sale – 20%
♨️ Pre-Sale – 40%
♨️ Liquidity – 14%
♨️ Airdrops – 10%
♨️ Staking – 6%
♨️ Team – 10%
✈️Contract Address: 0xC6ac148250736a67E84864Eae2B45A8a81D9e163
❄️ Join the community and feel the great vibe!
Ronin Games’ team have given you a wide variety of social platforms that you can engage with and communicate with other people in the project. Right there you can contact the team and ask them anything you feel like it! I have done it myself and they are flawless in their response.
♟️ Website:
✉️ Telegram:
☎️ Twitter:
submitted by drynionph to CryptoMoonCoins [link] [comments]

2021.12.02 10:21 JustTheRealNews Secretary Antony J. Blinken And Russian Foreign Minister Sergey Lavrov Remarks to the Press Before Their Meeting

Secretary Antony J. Blinken And Russian Foreign Minister Sergey Lavrov Remarks to the Press Before Their Meeting submitted by JustTheRealNews to JustTheRealNews [link] [comments]

2021.12.02 10:21 shibsocial DOGE and Shiba Inu: Identifying why more companies are accepting 'dog coins' - AMBCrypto News

DOGE and Shiba Inu: Identifying why more companies are accepting 'dog coins' - AMBCrypto News submitted by shibsocial to shibsocial [link] [comments]